NCT07529691

Survey on Physical Activity and Qualify of Life in Fibromuscular Dysplasia

National Survey of Physical Activity Restrictions and Quality of Life Among Patients With Fibromuscular Dysplasia

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Fibromuscular dysplasia (FMD) is a disease of the arteries that is not due to plaque build-up or inflammation. While some patients with FMD are health, some may experience heart attacks, strokes, aneurysms or blood vessel dissection/tearing which can be life-threatening. It predominantly impacts women and younger patients. As a result of this diagnosis, many patients are counseled to restrict or avoid certain physical activities out of concern for provoking or worsening vascular complications. There are no guidelines or consensus recommendations regarding appropriate physical activity for patients with FMD. The lack of consensus may lead to confusion for patients and may negatively impact their quality of life. This study will conduct a large, national survey of patients with FMD to assess the type of physical activity restrictions and impact on quality of life and emotional well-being.

Detailed description

Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disease of medium-sized arteries characterized by intimal and medial hyperplasia. The exact prevalence of FMD is unknown, but it predominantly impacts women and middle-age patients, with a mean age of 52 at the time of diagnosis. The manifestations of FMD are variable and may include spontaneous coronary artery dissection (SCAD) as well as extra-coronary vascular abnormalities (EVAs), such as peripheral artery aneurysms or dissections. Many patients are counseled to restrict or avoid certain physical activities out of concern for provoking or worsening vascular complications.3,4 However, there are no guidelines or consensus recommendations regarding appropriate physical activity for patients with FMD in the available 2018 American Heart Association (AHA) Scientific statement or the 2019 first international consensus document on FMD. Recommendations are formed based on expert opinion, and may vary based on a variety of factors including severity of disease, treating institution, or sex. The lack of consensus may lead to confusion for patients and may negatively impact their quality of life. This survey will be delivered electronically via RedCap to participants who self-identify as having a diagnosis of fibromuscular dysplasia. It will be the first to identify the breadth and content, as well as the impact, of physical activity recommendations provided by healthcare personnel to patients with FMD. Data gathered from this study will encourage the creation of an expert consensus document on recommendations for physical activity by FMD phenotype, which will have implications for patient education and empowerment for those living with FMD. This may also lead to areas of future intervention to mitigate adverse quality of life if identified.

Conditions

• Fibromuscular Dysplasia of Arteries
• Fibromuscular Dysplasia
• Spontaneous Coronary Artery Dissection

Timeline

• Start date: 2026-04-15
• Primary completion: 2027-04-30
• Completion: 2027-06-30
• First posted: 2026-04-14
• Last updated: 2026-04-14

Locations

1 site across 1 country: United States