NCT07528820

Inflammatory Profiles, Histopathological Features, and Remodeling Factors in Chronic Rhinosinusitis With Nasal Polyps

Investigating Sinonasal Inflammatory Profiles, Histopathological Features, and Remodeling Factors in Chronic Rhinosinusitis Patients With Nasal Polyposis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: St. Paul's Sinus Centre · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This study aims to examine three key aspects of chronic rhinosinusitis with nasal polyps (CRSwNP): inflammation, tissue structure (histopathology), and remodeling.

Detailed description

By analyzing these tissue samples before and after treatment with intranasal corticosteroids (INCS), investiagtors hope to better understand how the nasal tissue changes and whether those changes are linked to improvements in symptoms. This information could help doctors create more personalized treatment plans for people with CRSwNP in the future.

Conditions

• CRSwNP
• Chronic Rhinosinusitis (Diagnosis), Nasal Polyposis

Interventions

Type	Name	Description
DRUG	Budesonide	Participants will use Budesonide twice daily

Timeline

• Start date: 2026-07-01
• Primary completion: 2026-07-01
• Completion: 2026-08-01
• First posted: 2026-04-14
• Last updated: 2026-04-14

Locations

1 site across 1 country: Canada