NCT07528339

Prospective RegIstry for Oncologic Reirradiation (PRIOR-DK)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aims to provide a setup for collecting radiotherapy-related toxicity data, loco-regional control, and overall survival data for all Danish cancer patients undergoing reirradiation with high dose intention or with the aim of local tumour control; with the ultimate aim of providing safe reirradiation to a larger group of patients. To build a reirradiation cohort database for future research

Detailed description

Reirradiation of recurrent or new tumours has been associated with high rates of severe and even lethal toxicity in some previous reports \[Andratscske2023\]. This has led to many patients not being offered high dose reirradiation, even though they may potentially benefit from effective local treatment. Thus, it is extremely important to establish solid evidence of the risk of severe toxicity, to enable radiotherapy to be offered to these patients on an equal footing with patients treated for their first cancer. This prospective registration study will form the basis of a database enabling us to learn more about which patients are suitable for reirradiation, optimal constraints for organs at risk in reirradiation, overall survival, etc.

Conditions

• Radiotherapy Side Effect

Interventions

Type	Name	Description
RADIATION	Reirradiation	reirradiation with all available modalities can be included

Timeline

• Start date: 2026-04-01
• Primary completion: 2032-03-31
• Completion: 2037-03-31
• First posted: 2026-04-14
• Last updated: 2026-04-14