NCT07527338

Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use

• Status: Not Yet Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 58 (estimated)
• Sponsor: University of Colorado, Boulder · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if cannabidiol helps to improve sleep and decrease alcohol use. It will also learn about the safety of cannabidiol. The main questions it aims to answer are: Does 4 weeks of nightly cannabdiol use: 1. improve sleep quality and time spent in REM sleep? 2. decrease alcohol use and alcohol craving? 3. pose any safety risks? Researchers will compare cannabidiol to a placebo (a look-alike substance that contains no drug). Participants will: Take cannabidiol every night for 4 weeks Visit the clinic once at the beginning and once at the end of the study Wear an activity monitoring watch while in the study Complete an at-home sleep test both at the beginning and the end of the study Check in once a week with researchers via video conference

Conditions

• Sleep
• Alcohol Misuse

Interventions

Type	Name	Description
DRUG	Cannabidiol	300mg broad spectrum hemp extract in 50mg softgels
DRUG	Placebo	Taste and appearance matched softgel with hemp seed oil, glycerin, and gelatin

Timeline

• Start date: 2026-05-01
• Primary completion: 2031-04-30
• Completion: 2031-04-30
• First posted: 2026-04-14
• Last updated: 2026-04-16

Regulatory

• FDA-regulated drug study