NCT07526883

The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Istanbul University · Academic / Other
• Sex: All
• Age: 19 Years – 36 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were: Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis? Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment? Researchers compared participants with severe periodontitis to healthy participants without periodontitis. Participants with severe periodontitis: * Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved * Had full-mouth gum examinations * Provided blood samples at the start of the study and again at 2 and 6 months after treatment Healthy participants: * Had gum examinations * Provided blood samples for comparison at the start of the study

Conditions

• Periodontitis, Aggressive

Interventions

Type	Name	Description
PROCEDURE	Non-surgical periodontal treatment	Non-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment.

Timeline

• Start date: 2006-07-01
• Primary completion: 2009-12-01
• Completion: 2010-06-01
• First posted: 2026-04-13
• Last updated: 2026-04-13

Locations

1 site across 1 country: Turkey (Türkiye)