NCT07526077

Physiology-Guided Airway Preparation Enhances Hemodynamics and Cerebral Oxygenation

Physiology-Guided Airway Preparation Using Standard Oxygen Therapy Improves Hemodynamic Stability and Cerebral Oxygenation During Induction of Anesthesia for Major Spinal Surgery: A Randomized Controlled Trial

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: Prince Sultan Military Medical City · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study looked at a safer way to prepare patients for anesthesia before major spinal surgery. Instead of using advanced or complex oxygen devices, the approach used standard oxygen methods, guided by the patient's individual physiological responses (such as oxygen levels and circulation).

Detailed description

We proposed that a physiology-guided airway preparation approach, relying solely on conventional oxygen delivery methods, would enhance haemodynamic stability and cerebral oxygenation during anaesthetic induction in patients undergoing major spinal surgery. The findings are intended to improve patient safety, support better intraoperative decision-making, and potentially encourage wider integration of cerebral oximetry into perioperative neuroprotection strategies.

Conditions

• Airway Reactivity
• Hemodynamic Stability During Anesthesia

Interventions

Type	Name	Description
PROCEDURE	regional cerebral oxygen saturation	By employing multi-wavelength technology on the forehead, the O3 device provides clinicians with crucial insights into the balance between cerebral oxygen demand and supply. This monitoring is especially valuable for high-risk patient populations, such as those undergoing cardiac surgery, and patients in the intensive care unit (ICU), which provides a continuous, non-invasive assessment of rSO₂ enabling the prompt detection of critical desaturation events. Crucially, changes in rSO₂ during induction correlate with factors directly relevant to spinal cord safety, such as hypotension, hypocapnia, and reduced cardiac output.

Timeline

• Start date: 2026-04-10
• Primary completion: 2026-08-15
• Completion: 2026-08-30
• First posted: 2026-04-13
• Last updated: 2026-04-16

Locations

1 site across 1 country: Saudi Arabia