NCT07525648

Comparison of the Effects of Sevoflurane and Desflurane on Optic Nerve Sheath Diameter During Laparoscopic Surgery

Comparison of the Effects of Sevoflurane and Desflurane Used for Anesthesia Maintenance on Optic Nerve Sheath Diameter in the Trendelenburg Position

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Medipol University · Academic / Other
• Sex: Female
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Laparoscopic surgeries require pneumoperitoneum and Trendelenburg position, which may lead to increased intracranial pressure (ICP). Optic nerve sheath diameter (ONSD) measurement via ultrasound is a non-invasive method to evaluate ICP. This prospective study aims to compare the effects of sevoflurane and desflurane on ONSD in patients undergoing laparoscopic hysterectomy and bilateral oophorectomy in the Trendelenburg position.

Detailed description

The primary objective of this study is to compare the ONSD values measured by ultrasound between the sevoflurane and desflurane groups. The secondary objective is to evaluate the relationship between ONSD changes, hemodynamic parameters, and postoperative neurological complications.

Conditions

• Intracranial Pressure
• Laparoscopic Surgery
• Optic Nerve Sheath Diameter

Interventions

Type	Name	Description
DRUG	Sevoflurane	Anesthesia maintenance will be provided with sevoflurane at 1 MAC in a 40% oxygen-air mixture.
DRUG	Desflurane	Anesthesia maintenance will be provided with desflurane at 1 MAC in a 40% oxygen-air mixture.

Timeline

• Start date: 2026-04-15
• Primary completion: 2026-05-10
• Completion: 2026-05-15
• First posted: 2026-04-13
• Last updated: 2026-04-17

Locations

1 site across 1 country: Turkey (Türkiye)