NCT07525440

Neural Respiratory Drive Combined With Pro-Brain Natriuretic Peptide (Pro-BNP) as Predictor of Deterioration After Lung Transplantation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: The First Affiliated Hospital of Guangzhou Medical University · Academic / Other
• Sex: All
• Age: 20 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Lung transplantation has become a promising therapeutic option for various end-stage lung diseases. However, many factors such as infection, graft rejection, airway complications would cause deterioration and shorten the survival time. It is important to detect the deterioration early and receive treatment timely, which may enhance survival. We hypothesis the decreased neural respiratory drive(NRD) would be increased in the deterioration due to the aggravation of lung. Furthermore, pro-Brain Natriuretic Peptide(pro-BNP) has been reported to be associated with greater mortality after lung transplantation.For this reason, we investigated the NRD and pro-BNP before and after lung transplantation and during deterioration. 80 patients were recruited.They were end-stage lung disease patients admitted to hospital for lung transplantation. The NRD and pro-BNP were monitored before and after lung transplantation.we investigated the NRD and pro-BNP before and after lung transplantation and during deterioration.

Conditions

• Lung Transplantation

Interventions

Type	Name	Description
OTHER	No Intervention: Observational Cohort	no intervention

Timeline

• Start date: 2016-01-01
• Primary completion: 2026-02-01
• Completion: 2026-02-01
• First posted: 2026-04-13
• Last updated: 2026-04-13

Locations

1 site across 1 country: China