NCT07524556

Walking Fatigability,Saptiotemporal Gait Parameters and Falling in MS Patients

Influance of Walking Fatigability on Spatiotemporal Gait Parameters and Risk of Falling in Patients With Multiple Scalerosis

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 62 (estimated)
• Sponsor: Ibrahim Ahmad Elmongy · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This observational study aims to investigate the relationship between walking fatigability, changes in spatiotemporal gait parameters, and risk of falling in individuals with multiple sclerosis (MS). Participants will be divided into two groups: those with walking fatigability and those without. Each participant will undergo functional tests to detect deterioration in patiotemoral gait parameters and risk of falling . The results of this study will help understand how walking fatigability affects gait and fall risk in MS, providing insights for rehabilitation strategies.

Detailed description

Multiple sclerosis (MS) is a chronic neurological disease that often affects mobility, balance, and endurance. Walking fatigability, defined as a decline in walking performance over time, is a common problem in individuals with MS and may increase the risk of falls. Understanding how walking fatigability influences gait patterns and fall risk is essential for designing targeted rehabilitation strategies. This observational study aims to investigate the relationship between walking fatigability, spatiotemporal gait parameters, and fall risk in individuals with MS. Participants will be recruited from Alexandria University Hospital and will be divided into two groups based on the presence or absence of walking fatigability. Inclusion criteria include confirmed MS diagnosis, ability to walk independently, and willingness to provide informed consent. Exclusion criteria include acute MS relapse, comorbid conditions affecting gait, or cognitive impairment that prevents safe participation. Participants will undergo 6-Minute Walk Test to assess walking performance, and gait parameters such as step length and double time support.and gait speed will be recorded. Fall risk will be evaluated using a Timed Up and Go (TUG) test and The Falls Efficacy Scale-International (FES-I). Data will be analyzed to compare gait changes and fall risk between the two groups. Correlations between walking fatigability and specific gait parameters will be explored to identify patterns associated with higher fall risk. The findings of this study are expected to inform clinical decision-making and rehabilitation approaches, contributing to safer and more effective mobility management for individuals with MS.

Conditions

• Multiple Sclerosis

Timeline

• Start date: 2026-04-01
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2026-04-13
• Last updated: 2026-04-13

Locations

1 site across 1 country: Egypt