NCT07522216

Effect of Clear Aligner Wear Protocol on External Root Resorption

Effect of Clear Aligner Wear Protocol on External Root Resorption: A Randomized Controlled Clinical Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Jordan University of Science and Technology · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The aim of this two-arm randomized clinical trial was to compare the effect of 7-day and 14-day orthodontic clear aligner wear protocols on external apical root resorption (EARR) and pain perception

Detailed description

Fifty adult patients (21 Male and 29 female with a mean age of 23.7 ± 1.8) presented at the postgraduate orthodontic clinics at Jordan University of Science and Technology (JUST) were randomly allocated into a 7-day or 14-day aligner change protocol. Each patient underwent a standardized series of digital periapical radiographs (three upper and three lower). Baseline radiographs (T0) were taken before the initiation of treatment, and follow-up radiographs (T1) were collected after six months of aligner therapy. EARR was measured from a line drawn at the cemento-enamel junction (CEJ) to the tooth's apex before treatment (T₀), and after treatment (T1), the difference in length was calculated and graded using the Malmgren Index. Pain perception was assessed using a verbal rating scale (VRS) at six-time intervals (24 hours, first week, second week, first month, third month and sixth month). Statistical analyses were used to compare pre- and post-treatment changes within and between the groups. Multiple linear regression was used to identify predictors of EARR.

Conditions

• Clear Aligner Therapy

Interventions

Type	Name	Description
OTHER	Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols	One group should change the orthodontic clear aligner every week (7 days) and the second group every two weeks (14 days)

Timeline

• Start date: 2025-02-02
• Primary completion: 2026-04-01
• Completion: 2026-05-15
• First posted: 2026-04-13
• Last updated: 2026-04-13

Locations

1 site across 1 country: Jordan