NCT07521267

Nano Coated Orthodontic Miniscrews for en Mass Retraction of the Upper Arch

Evaluation of Silver-Hydroxyapatite Nano-coated Versus Uncoated Orthodontic Miniscrews for en Masse Retraction of the Upper Anterior Segment: A Randomized Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 14 Years – 20 Years
• Healthy volunteers: Not accepted

Summary

study will be directed to evaluate silver-hydroxyapatite nano-coated versus uncoated orthodontic miniscrews for en masse retraction of the upper anterior segment.

Detailed description

Silver-hydroxyapatite nanoparticles (Ag-HA NPs) have lately gained popularity in dentistry due to their unique combination of silver antibacterial activity and hydroxyapatite's osteoconductive, remineralizing characteristics. Ag-HA has shown potential in resolving two important clinical issues: infection control and anchoring stability. Coating orthodontic miniscrews with Ag-HA NPs has been demonstrated to reduce peri-implant biofilm growth by their antimicrobial effect, minimizing inflammation, and increasing osseointegration, thus increasing the long-term success of temporary anchoring devices (TADs).

Conditions

• Class I Malocclusion
• Maxillary Prognathism
• Orthodontic Tooth Movement

Interventions

Type	Name	Description
DEVICE	Silver nanoparticles	Patients will receive silver-hydroxyapatite nanocoated titanium miniscrews.These miniscrews will be placed in the maxillary bone for en masse retractonof the upper anterior teeth.
DEVICE	uncoated titanium miniscrews	Patients will receive conventional uncoated titanium miniscrews of the same dimensions and design as the intervention of the group1, but without nano-coating.

Timeline

• Start date: 2026-05-01
• Primary completion: 2028-06-01
• Completion: 2029-11-01
• First posted: 2026-04-09
• Last updated: 2026-04-13

Locations

1 site across 1 country: Egypt