NCT07521150

Physiotherapy and Rehabilitation in Melorheostosis: A Case Report

The Role of Physiotherapy and Rehabilitation in a Patient Diagnosed With Melorheostosis: A Case Report

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (estimated)
• Sponsor: Yeditepe University · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the effects of a structured physiotherapy and rehabilitation-based exercise program on clinical and functional parameters in a patient diagnosed with melorheostosis. This study specifically aims to assess the effects of a structured physiotherapy and rehabilitation-based intervention program, including patient education and therapeutic exercise, on lower extremity functional parameters, muscle strength, balance, and quality of life in a patient with melorheostosis. The main hypotheses: H0: A structured physiotherapy and rehabilitation-based exercise program has no effect on improvement in clinical and functional evaluation parameters in a patient with melorheostosis. H1: A structured physiotherapy and rehabilitation-based exercise program leads to improvement in clinical and functional evaluation parameters in a patient with melorheostosis.

Detailed description

Melorheostosis is a rare, chronic, and progressive sclerosing bone disorder characterized by cortical bone thickening, pain, joint stiffness, restricted mobility, and functional impairment. Due to its low prevalence, the available literature is limited, and conservative management strategies, particularly physiotherapy interventions, remain insufficiently defined. A patient diagnosed with melorheostosis who meets the inclusion criteria and is followed by an orthopedic specialist will be included in this prospective single-case study to investigate the effectiveness of a structured physiotherapy and rehabilitation-based exercise program. The patient, who is under regular physician supervision and willing to participate in the rehabilitation program, will be included in the study. The intervention approach will be based on a non-invasive, exercise-oriented physiotherapy program. The rehabilitation program will consist of patient education, diaphragmatic breathing training, and a structured exercise program including strength, flexibility, and balance components. The patient will participate in a total of 24 physiotherapy sessions, three days per week, for eight weeks. Before starting the treatment program, the patient's sociodemographic characteristics, medical history, and disease-related clinical features will be recorded using a structured evaluation form. A baseline clinical evaluation will be performed prior to the intervention. Following the baseline assessment, the individualized physiotherapy program will be implemented. Exercise intensity and progression will be adjusted according to the patient's pain level and functional capacity throughout the intervention period. Clinical and functional parameters will be evaluated before the treatment, immediately after the 8-week intervention, and at a 6-month follow-up to assess both short-term and long-term effects. Throughout the study, the patient will continue routine medical treatment and remain under physician supervision, and no changes will be made to the existing medical management.

Conditions

• Melorheostosis

Interventions

Type	Name	Description
OTHER	Assigned Interventions	Patient will receive patient education in addition to a structured exercise program. The exercise program will include progressive strengthening, flexibility, and balance-based exercises. Patient education will be delivered by targeting topics that encompass all components of the ICF framework. In addition, diaphragmatic breathing will be taught to patients prior to the exercise program. The exercise program will be conducted three times per week for 8 weeks. Baseline assessments will be performed before the intervention, and post-intervention assessments will be repeated after completion of the program. Furthermore, evaluations will be conducted again during a 6-month follow-up period.

Timeline

• Start date: 2026-03-17
• Primary completion: 2026-05-19
• Completion: 2026-09-22
• First posted: 2026-04-09
• Last updated: 2026-04-09

Locations

1 site across 1 country: Turkey (Türkiye)