NCT07514663

Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile

A Randomized, Double-Blind, Controlled Feeding, Crossover Trial to Assess the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile in Men and Women

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (estimated)
• Sponsor: Midwest Center for Metabolic and Cardiovascular Research · Academic / Other
• Sex: All
• Age: 18 Years – 74 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to assess the effects of corn and avocado oils as part of controlled feeding diets on the cardiometabolic risk factor profile in men and women with mild-to-moderately elevated levels of non-high-density lipoprotein cholesterol (non-HDL-C). Participants will be asked to consume the controlled feeding diet for two separate 21 day conditions, and will consume their regular diet for a 21 day washout period between the two conditions. Additionally, participants will be asked to come into the clinic on 7 different occasions, including one screening visit (visit 1, -7 days), one baseline visit (visit 2, day 0), two visits during each 21-d diet condition (visits 3 \& 6, day 19 and visits 4 \& 7, day 21), and a visit at the conclusion of the washout phase/start of the second diet condition (visit 5, day 0).

Conditions

• Hypercholesterolemia

Interventions

Type	Name	Description
OTHER	corn oil	Corn oil will be provided in yogurt, rolls and muffins throughout the study period.
OTHER	Avocado Oil	Avocado oil will be provided in yogurt, rolls and muffins throughout the study period.

Timeline

• Start date: 2026-04-10
• Primary completion: 2026-09-01
• Completion: 2026-09-01
• First posted: 2026-04-07
• Last updated: 2026-04-17

Locations

1 site across 1 country: United States