NCT07514624

CRIC Combined With MFT for MFR in Patients With Incomplete Revascularization of CAD

Chronic Remote Ischemic Conditioning Combined With Mindfulness Therapy for Myocardial Flow Reserve in Patients With Incomplete Revascularization of Coronary Artery Disease: A Multicenter, Double-blind, Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 480 (estimated)
• Sponsor: Henan Institute of Cardiovascular Epidemiology · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study is to demonstrate whether the combination of chronic remote ischemic conditioning and mindfulness therapy can improve myocardial flow reserve in patients with incomplete revascularization of coronary artery disease.

Conditions

• Coronary Disease

Interventions

Type	Name	Description
DEVICE	CRIC	chronic remote ischemic conditioning Using a semi-automated machine, the pressure is increased according to the patient's own blood pressure level (20-40mmHg) when the cuff is pressed, and the pressure is squeezed for 6 minutes per cycle and the rest is 4 minutes, for a total of 4 cycles per cycle.
BEHAVIORAL	MFT	Participants receive guided mindfulness audio sessions twice daily for \~30 minutes each throughout the perioperative period. Content includes standardized mindfulness practices (e.g., focused attention, body awareness, nonjudgmental observation) designed to reduce anxiety and improve sleep quality.
DEVICE	sham CIRC	The pressure was 60mmHg when the cuff was pressurized, and the other modes were the same as in the CIRC group.
BEHAVIORAL	sham MFT	A time- and attention-matched audio program (twice daily, 30 minutes) delivering perioperative recovery and sleep-hygiene education with passive relaxation (music or simple muscle loosening), excluding mindfulness-specific techniques (no present-moment/ nonjudgmental awareness training, no breath-focused meditation, no open monitoring).

Timeline

• Start date: 2026-05-01
• Primary completion: 2028-09-01
• Completion: 2028-12-01
• First posted: 2026-04-07
• Last updated: 2026-04-07