NCT07514234

Optimal Allogeneic PRP Concentration for Oocyte In Vitro Maturation in Women With PCOS

Optimal Allogenic Platelet-rich Plasma Concentration to Improves in Vitro Maturation of Germinal Vesicle Oocytes From Women With PCOS: A Prospective Cohort Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Gadjah Mada University · Academic / Other
• Sex: Female
• Age: 30 Years – 41 Years
• Healthy volunteers: Not accepted

Summary

In vitro maturation is a long-studied technique used to obtain mature oocytes outside the human body. However, this method can increase the risk of ovarian hyperstimulation syndrome (OHSS), particularly in patients with polycystic ovarian syndrome (PCOS). Culture media supplemented with platelet-rich plasma (PRP) has previously shown promise for improving oocyte maturation. This study examined the potential utility of allogeneic PRP supplementation to increase the maturation of germinal vesicle (GV)-stage oocytes collected from PCOS patients who underwent controlled ovarian stimulation. Supplementation with 5% PRP was found to support oocyte maturation under controlled ovarian stimulation. Further investigations are required to refine the use of PRP without controlled ovarian stimulation in clinical IVM protocols that may be beneficial for PCOS patients.

Conditions

• PCOS (Polycystic Ovary Syndrome)

Interventions

Type	Name	Description
OTHER	PRP plasma rich platelets	An initial pilot experiment tested three different concentrations of PRP supplementation (5%, 25%, and 50%)

Timeline

• Start date: 2023-01-05
• Primary completion: 2023-09-11
• Completion: 2025-12-09
• First posted: 2026-04-07
• Last updated: 2026-04-07

Locations

1 site across 1 country: Indonesia