NCT07513818

IMPLEMENTING LOW-DOSE CT LUNG CANCER SCREENING IN FRANCE

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20,000 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 50 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

The main objective is to estimate the detection rate of lung cancer in the population screened by low-dose chest CT scans.

Detailed description

Low-dose CT screening (LDCT) allows for the detection of lung cancer at an early stage, enabling curative treatment. Large randomized controlled trials have demonstrated that LDCT reduces mortality in smokers. The objective of the current research is not to confirm a reduction in mortality, but to show that screening can be safely implemented at a population level. Different modes of recruitment and invitation will be tested to ensure that LDCT can be implemented equitably. The role of artificial intelligence as an alternative to double human reading will also be assessed. Screening strategy includes baseline, followed by 1-year LDCT, and a third LDCT 2 years later. Current smokers will be offered smoking cessation support. The management of screen-detected lung nodules will follow the 2025 guidelines from the European Society of Thoracic imaging.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
PROCEDURE	Low-dose computed tomography of the chest	Baseline low-dose CT acquisition, then at 1 year and 3 years to depict suspicious lung nodules

Timeline

• Start date: 2026-06-01
• Primary completion: 2031-06-01
• Completion: 2031-12-01
• First posted: 2026-04-07
• Last updated: 2026-04-07

Locations

2 sites across 1 country: France