NCT07511491

Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in Cesarean Section

Effect of Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in Cesarean Section: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare the effect of ondansetron lozenge and intravenous for prevention of shivering in cesarean section (CS).

Detailed description

Spinal anesthesia has many advantages when used for cesarean section (CS). It is a popular technique with rapid onset and high success rate. Shivering is associated with increased metabolic activity and consumption of oxygen. In addition, arterial hypoxia, lactic acidosis, and interference with electrocardiogram monitoring could be associated with shivering. Ondansetron is a selective antagonist for receptor 5-hydroxytryptamine 3 and is very effective in the prevention and treatment of shivering intra- and post-operation. This medicine also decreases nausea and vomiting intra-and post-operatively.

Conditions

• Ondansetron
• Lozenge
• Intravenous
• Prevention
• Shivering
• Cesarean Section

Interventions

Type	Name	Description
DRUG	Ondansetron lozenge	Patients will receive ondansetron lozenge 4 mg (Ondalenz ©), 2 hours before surgery.
DRUG	Ondansetron intravenous	Patients will receive 8 mg of ondansetron IV just before the surgery.

Timeline

• Start date: 2026-04-11
• Primary completion: 2026-10-01
• Completion: 2026-10-01
• First posted: 2026-04-06
• Last updated: 2026-04-14

Locations

1 site across 1 country: Egypt