Trials / Recruiting

RecruitingNCT07511283

Calciphylaxis in Patients With Chronic Kidney Disease - A Study of the Danish Calciphylaxis Research Initiative (DanCaRI)

Status: Recruiting
Phase: —
Study type: Observational
Enrollment: 860 (estimated)

Sponsor: Odense University Hospital · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Accepted

Summary

Calciphylaxis is a rare yet life-threatening condition involving pronounced calcification in small blood vessels of the skin. Knowledge about its underlying mechanisms and contributing risk factors remains limited. Chronic kidney disease is one of the strongest disease predictors. No evidence based effective therapy is currently available. Research on the topic is mainly hindered by the condition's rarity. The study Calciphylaxis in patients with chronic kidney disease - A study of the Danish Calciphylaxis Research Initiative (DanCaRI) is set up to facilitate the systematic retrospective and prospective comparison of patients with chronic kidney disease and calciphylaxis to matched patients with chronic kidney disease who did not develop calciphylaxis thereby providing new knowledge that can support prevention, early detection, and new treatment approaches.

Detailed description

Calciphylaxis is a rare yet life-threatening condition involving pronounced calcification in small blood vessels of the skin. Knowledge about its underlying mechanisms and contributing risk factors remains limited. Chronic kidney disease is one of the strongest disease predictors. No evidence based effective therapy is currently available. Research on the topic is mainly hindered by the condition's rarity. The study Calciphylaxis in patients with chronic kidney disease - A study of the Danish Calciphylaxis Research Initiative (DanCaRI) is set up to facilitate the systematic retrospective (two years) and prospective (three years follow-up period) comparison of patients with chronic kidney disease and calciphylaxis (cases) to matched patients with chronic kidney disease who did not develop calciphylaxis (controls) thereby providing new knowledge that can support prevention, early detection, and new treatment approaches. The study collects clinical data and biological samples. A healthy group is part of the study to enable comparison to reference parameters.

Conditions

Timeline

Start date: 2026-04-01
Primary completion: 2040-06-01
Completion: 2040-06-01
First posted: 2026-04-06
Last updated: 2026-04-06

Locations

1 site across 1 country: Denmark

Source: ClinicalTrials.gov record NCT07511283. Inclusion in this directory is not an endorsement.