Trials / Completed
CompletedNCT07510997
Perioperative Individually Tailored Psychological Intervention in Breast Cancer Surgery
Perioperative Individually Tailored Psychological Intervention in Breast Cancer Patients Improves Psychological Indices and Molecular Biomarkers of Metastasis in Excised Tumors
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- Rabin Medical Center · Academic / Other
- Sex
- Female
- Age
- 20 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
This randomized controlled trial examined whether a perioperative individually tailored psychological intervention can reduce psychological distress and modulate pro-metastatic molecular processes in breast cancer patients undergoing surgery. Forty women with stage I-III breast cancer were randomized to receive either a 6-week individualized psychological intervention or standard nursing care. Primary outcomes included tumor gene expression profiles associated with adrenergic, inflammatory, and metastatic signaling pathways. Secondary outcomes included psychological distress, stress, and resilience measures assessed across multiple perioperative time points.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Individually Tailored Perioperative Psychological Intervention | A 6-week individually tailored psychological intervention delivered perioperatively, including six sessions with a trained medical psychologist and bi-weekly phone calls. The intervention targets emotional, cognitive, physiological, and behavioral stress responses, and includes psychoeducation, stress-reduction techniques, coping strategies, and enhancement of social support, based on individual patient needs assessed before surgery. |
| OTHER | Standard Nursing Care | Standard nursing staff attention (treatment-as-usual) without structured psychological intervention. |
Timeline
- Start date
- 2018-01-01
- Primary completion
- 2021-12-31
- Completion
- 2022-12-31
- First posted
- 2026-04-06
- Last updated
- 2026-04-06
Locations
1 site across 1 country: Israel
Source: ClinicalTrials.gov record NCT07510997. Inclusion in this directory is not an endorsement.