NCT07509762

Exercise Programs in Women With PCOS

Investigation of the Effectiveness of a Digital Rehabilitation-Supported Combined Exercise Program in the Management of Polycystic Ovary Syndrome

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (estimated)
• Sponsor: Biruni University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the effectiveness of a digital rehabilitation-supported combined exercise program in women with Polycystic Ovary Syndrome (PCOS). Participants aged 18-40 years will be randomly assigned to one of three groups: a digital rehabilitation group, a face-to-face exercise group, and a physical activity counseling group. The intervention will last 8 weeks, with exercise performed three times per week. Outcomes will include DNA methylation, hormonal and metabolic parameters, anthropometric measurements, body composition, muscle strength, basal metabolic rate, physical activity level, quality of life, menstrual cycle regularity, exercise adherence and satisfaction.

Detailed description

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder associated with metabolic, hormonal, and reproductive dysfunctions. Exercise is a key component in the management of PCOS; however, adherence to exercise programs remains a major challenge. This randomized controlled trial aims to evaluate the effectiveness of a digital rehabilitation-supported combined exercise program compared to face-to-face supervised exercise and physical activity counseling. Participants aged 18-40 years will be randomly assigned into three groups: 1. Face-to-face exercise group 2. Digital rehabilitation group 3. Physical activity counseling group The intervention will last for 8 weeks, with exercise sessions conducted three times per week. The face-to-face group will participate in supervised exercise sessions conducted by physiotherapist. The digital rehabilitation group will perform the same exercise protocol as the face-to-face group group online, live (synchronously), under the guidance of physiotherapist. The counseling group will receive physical activity recommendations. Outcome measures will include epigenetic changes (DNA methylation), hormonal and metabolic parameters, anthropometric measurements, body composition, muscle strength, basal metabolic rate, physical activity level, quality of life, menstrual cycle regularity, exercise adherence and satisfaction.

Conditions

• Polycystic Ovarian Syndrome (PCOS)
• Digital Rehabilitation
• DNA Methylation
• Exercise

Interventions

Type	Name	Description
BEHAVIORAL	Face-to-face exercise	Participants will perform the same combined exercise program (aerobic and resistance exercises) delivered in person by the study team. Sessions are supervised directly in a clinical setting.
BEHAVIORAL	Digital rehabilitation	Participants will perform a combined exercise program (aerobic and resistance exercises) through a digital rehabilitation platform.

Timeline

• Start date: 2026-09-01
• Primary completion: 2027-01-15
• Completion: 2027-03-25
• First posted: 2026-04-03
• Last updated: 2026-04-03

Locations

1 site across 1 country: Turkey (Türkiye)