NCT07507474

Performance of the Treatment of Periodontitis According to the Bioperio® Protocol

Performance of the Treatment of Periodontitis According to the Bioperio® Protocol: a Prospective Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 600 (estimated)
• Sponsor: University of Pisa · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This multicenter, prospective, single-arm observational study evaluated the 3-month clinical performance of the Bioperio® protocol, a standardized, patient-centered framework for managing periodontitis. The protocol combined professional supra-gingival scaling, oral hygiene instruction and motivation, full-mouth subgingival instrumentation, and-in Stage III/IV cases-adjunctive enamel matrix derivative application in deep pockets.

Conditions

• Periodontitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	periodontal probing and charting	All clinical periodontal parameters were assessed at baseline and at the 3-month follow-up by calibrated examiners. Probing Instrument: A manual periodontal probe (UNC 15, Hu-Friedy, Chicago, IL, USA) was used. Examiners were calibrated to apply a consistent probing force of 0.25 N using a force-measuring scale. Measurements: For each tooth, six sites were examined: mesiobuccal, mid-buccal, distobuccal, mesiolingual, mid-lingual, and distolingual. Probing Pocket Depth (PPD): Measured in millimeters from the gingival margin to the base of the pocket; rounded to the nearest millimeter. Gingival Recession (REC): Measured in millimeters from the cementoenamel junction to the gingival margin; recorded as a positive value when the gingival margin was apical to the cementoenamel junction. Clinical Attachment Level (CAL): Calculated as PPD + REC for each site. Bleeding on Probing (BOP): Recorded dichotomously (present/absent) at the same six sites per tooth. The full-mouth bleeding score

Timeline

• Start date: 2023-12-05
• Primary completion: 2025-07-05
• Completion: 2030-12-05
• First posted: 2026-04-02
• Last updated: 2026-04-08

Locations

1 site across 1 country: Italy