NCT07506252

Influence of Hydration Status on the Yield of Injectable Platelet-Rich Fibrin

Influence of the Drinking Amount on the Autologous Blood in the Centrifuge Contained Fibrin Matrix - Platelet-rich Fibrin A Randomized Controlled Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Medical University of Graz · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Due to the current lack of evidence regarding the influence of fluid intake on the amount of leukocyte- and platelet-rich fibrin fraction present in blood samples, this study aims to investigate the positive influence of this factor on the body's own matrix. Platelet-rich fibrin, a fibrin-rich autologous matrix obtained from autologous blood via centrifugation, contains not only fibrin but also important growth factors and a large number of white blood cells, all of which make a significant contribution to tissue regeneration. The obtained fibrin matrix can be used as a membrane, as a clot (A-PRF), or as a liquid (i-PRF) to positively influence the healing process. The novelty of this work lies in shifting the focus from purely technical centrifugation parameters to a patient-centered, easily modifiable biological variable. Hydration status represents a low-cost, non-invasive, and immediately applicable strategy to optimize autologous blood concentrates. These findings are directly relevant to clinicians seeking to enhance the predictability and efficiency of PRF-based regenerative procedures in implant dentistry.

Conditions

• PRF
• Behavior Change Interventions
• Implant Dentistry

Interventions

Type	Name	Description
BEHAVIORAL	Hydration following a drinking protocol	Participants followed a drinking protocol the day before the measurement to reach euhydration

Timeline

• Start date: 2022-12-12
• Primary completion: 2023-05-19
• Completion: 2023-05-19
• First posted: 2026-04-01
• Last updated: 2026-04-01

Locations

1 site across 1 country: Austria