NCT07506044

Dexmedetomidine as an Adjuvant During Dural Puncture Epidural

The Effect of Different Doses of Dexmedetomidine as an Adjuvant to Bupivacaine for Parturients Having Dural Puncture Epidural Technique to Elaborate Labor Pain

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: Menoufia University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The study aimed to determine the effects of using varied doses of DEX on the concentration of bupivacaine injected for epidural labor analgesia, and to assess the benefits of the dural puncture epidural.

Detailed description

The primary efficacy point is the total dose of bupivacaine administered during labor. The secondary endpoints include the VAS pain scores, number of administered additional doses, incidence of motor block, delivery type (spontaneous vaginal or cesarean), maternal satisfaction, and complications such as hypotension, fetal bradycardia, and epidural-related maternal fever.

Conditions

• Total Dose of Bupivacaine Administered During Labor

Interventions

Type	Name	Description
DEVICE	Epidural Catheter with bupivacaine	epidural injection of plain Bup
DEVICE	Epidural with dural puncture	the dura is punctured by a 26-G spinal needle using the needle-through-needle technique, and is withdrawn after confirmation of free-flowing cerebrospinal fluid,
DRUG	Dexmedetomidine 0.4 added	Dexmedetomidine 0.4 added
DRUG	Dexmedetomidine 0.6 added	Dexmedetomidine 0.6 added

Timeline

• Start date: 2026-02-01
• Primary completion: 2026-08-01
• Completion: 2026-08-30
• First posted: 2026-04-01
• Last updated: 2026-04-01

Locations

1 site across 1 country: Egypt