NCT07500974

Efficacy of L-menthol on Breathlessness in Asthma

Effect of L-menthol on Breathlessness and Exercise Capacity in Asthma: a Randomized Crossover Trial

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Region Skane · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the effect of L-menthol on breathlessness and exercise capacity in patients with Asthma.

Detailed description

Dyspnea is a cardinal symptom in patients with lung disease, often triggered by daily-life physical activities. To date, an effective pharmacologic treatment to relieve chronic dyspnea is lacking. Recent pilot data support that inhaled L-menthol can markedly decrease laboratory-induced dyspnea in COPD and ILD patients, likely through increased afferent feedback of airflow in the airways by inducing a cooling sensation through olfactory stimulation. The aim of this study is therefore to assess the effectiveness and mechanisms of inhaled menthol for relief of patients with Asthma.

Conditions

• Asthma

Interventions

Type	Name	Description
DRUG	L-menthol	(Sigma-Aldrich, St. Louis, US)
OTHER	Placebo	Strawberry scent (Sigma-Aldrich, St. Louis, US)

Timeline

• Start date: 2026-05-01
• Primary completion: 2027-04-01
• Completion: 2027-05-01
• First posted: 2026-03-30
• Last updated: 2026-03-30

Locations

2 sites across 1 country: Sweden