NCT07500012

taVNS for Breast Cancer Pain and Symptom Management

Home-based Pain and Symptom Management for Breast Cancer Survivors: a Triple- Blinded RCT Pilot Study of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Florida State University · Academic / Other
• Sex: Female
• Age: 18 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

1. To evaluate the feasibility and acceptability of a home-based taVNS intervention and follow-up for pain and symptom management in breast cancer survivors. 2. To investigate the impact of taVNS on secondary outcomes, including pain, anxiety, depression, fatigue, and the brain-gut axis (BGA) in breast cancer survivors.

Conditions

• Breast Cancer Survivors

Interventions

Type	Name	Description
DEVICE	Active taVNS	practice the active taVNS twice daily for 30 minutes each over a 4-week period (56 sessions)
DEVICE	Sham taVNS	practice the sham taVNS twice daily for 30 minutes each over a 4-week period (56 sessions)

Timeline

• Start date: 2026-02-24
• Primary completion: 2027-12-01
• Completion: 2028-02-01
• First posted: 2026-03-30
• Last updated: 2026-03-30

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study