NCT07497685

Effects of Different Caffeine Forms on Aerobic and Anaerobic Exercise Performance

Comparative Acute Effects of Caffeine Delivery Forms (Capsule, Chewing Gum, Mouth Rinse) on Aerobic Capacity and Wingate Anaerobic Performance Outcomes in Recreational Male Athletes: A Randomized Counterbalanced Crossover Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: University of Gaziantep · Academic / Other
• Sex: Male
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This study investigated the effects of different caffeine delivery forms on aerobic and anaerobic exercise performance in healthy adults. Participants completed experimental trials involving caffeine capsule ingestion, caffeine gum chewing, and caffeine mouth rinse conditions. Aerobic performance was assessed using maximal oxygen uptake (VO2max), and anaerobic performance was evaluated using the Wingate anaerobic test. The study used a randomized crossover design where each participant completed all experimental conditions.

Detailed description

Caffeine is widely used as an ergogenic aid to enhance athletic performance. Different forms of caffeine administration such as capsules, chewing gum, and mouth rinses may produce different physiological responses due to differences in absorption rate and oral receptor stimulation. However, limited research has directly compared these delivery methods within the same participants. This randomized crossover study aimed to compare the effects of caffeine capsule ingestion, caffeine gum chewing, and caffeine mouth rinse on aerobic and anaerobic exercise performance. Fourteen healthy adults participated in the study and completed experimental trials under each caffeine condition. Aerobic performance was measured using maximal oxygen uptake (VO2max), while anaerobic performance was assessed using the Wingate anaerobic test. The results of this study may help clarify the effectiveness of different caffeine delivery forms for improving exercise performance.

Conditions

• Exercise Performance
• Physical Performance

Interventions

Type	Name	Description
OTHER	Comparative Acute Effects of Caffeine Delivery Forms (Capsule, Chewing Gum, Mouth Rinse) on Aerobic Capacity and Wingate Anaerobic Performance Outcomes in Recreational Male Athletes: A Randomized Coun	This study evaluates the acute effects of three distinct caffeine delivery methods compared to a placebo, using a standardized total dose of 300 mg of caffeine across all active interventions. The study is a randomized, single-blind, counterbalanced crossover trial involving 14 recreational male athletes. The interventions are distinguished by their specific absorption kinetics and ecologically valid administration timings

Timeline

• Start date: 2024-10-10
• Primary completion: 2024-11-10
• Completion: 2025-03-10
• First posted: 2026-03-27
• Last updated: 2026-03-27

Locations

1 site across 1 country: Turkey (Türkiye)