NCT07495605

Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.

Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp: A Randomized Clinical Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

To compare the effect of 1% melatonin gel versus calcium hydroxide as intra canal medication in necrotic mandibular premolars on: * Intensity of postoperative pain. * Bacterial load reduction. * Periapical (MMP-9) level.

Conditions

• Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp

Interventions

Type	Name	Description
DRUG	1% melatonin gel	1% melatonin gel: was prepared in the Drug Manufacture Unit, Faculty of Pharmacy, Cairo university
DRUG	Calcium Hydroxide (Ca(OH)2)	a water-soluble, premixed calcium hydroxide paste with barium sulfate, supplied in a 2.2g syringe

Timeline

• Start date: 2026-03-22
• Primary completion: 2027-12-01
• Completion: 2027-12-01
• First posted: 2026-03-27
• Last updated: 2026-03-27