NCT07495592

The Acute Effects of Onnit Alpha Brain on Cognition and Mood States

The Acute Effects of Onnit Alpha Brain on Cognition and Mood States: A Randomized, Crossover, Double Blind, Placebo-Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (estimated)
• Sponsor: Applied Science & Performance Institute · Industry
• Sex: All
• Age: 20 Years – 59 Years
• Healthy volunteers: Accepted

Summary

The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive performance, vigilance, and subjective mood in healthy adults compared to placebo during a period of acute sleep deprivation under conditions of controlled sleep deprivation.

Detailed description

Participants will complete three experimental conditions in a randomized order: Alpha Brain, Alpha Brain 2.0, and placebo. To avoid any possible crossover bias created by ingesting the supplements, the subjects should be appropriately counterbalanced using six possible sequences that all subjects will be equally shuffled through to help limit any bias. Each condition will be separated by a minimum 3-day washout period. Participants will undergo standardized cognitive testing, mood assessments, and safety monitoring following overnight sleep restriction. Primary outcomes include objective measures of vigilance and cognitive control, while secondary outcomes include subjective fatigue, mood state, and physiological safety measures.

Conditions

• Cognitive
• Mood and Cognitive Performance
• Sleep Deprivation
• Executive Function (Cognition)
• Fatigue

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Alpha Brain proprietary cognitive dietary supplement	Alpha Brain is a proprietary investigational dietary supplement. The formulation contains a combination of dietary ingredients commonly used in cognitive supplement mixes.
DIETARY_SUPPLEMENT	Alpha Brain 2.0 proprietary cognitive dietary supplement	Alpha Brain 2.0 is a proprietary investigational dietary supplement. The formulation contains a combination of dietary ingredients commonly used in cognitive supplements and will be evaluated under double-blind conditions in a randomized, placebo-controlled crossover study.
DIETARY_SUPPLEMENT	Controlled Placebo	The placebo consists of an inactive placebo mix administered orally as two capsules.

Timeline

• Start date: 2026-04-16
• Primary completion: 2026-08-01
• Completion: 2026-08-15
• First posted: 2026-03-27
• Last updated: 2026-04-03

Locations

1 site across 1 country: United States