NCT07495332

Siemens Biomarker Multi-modality

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see how well Photon Counting CT (PCCT) and ultrasound test results can find fat and scarring in the liver. They will be compared to MRI test results as the reference standard. Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study. They will also get an MRI, either on the same day or a different day, whichever is preferred. Participants will get an ultrasound on the same day as the MRI. If they have not had a hematocrit blood test in the past 24 hours, they will also receive one on the day of the CT scan.

Conditions

• Fatty Liver
• Hepatic Steatosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Photon-counting CT (PCCT)	Photon-counting computed tomography (PCCT) is a next-generation imaging technology using advanced detectors that directly count individual X-ray photons and measure their energy, rather than integrating total energy like traditional CT.
DIAGNOSTIC_TEST	Ultrasound	Ultrasound is a safe, radiation-free imaging technique using high-frequency sound waves to visualize soft tissues, organs, and blood flow in real-time.
DIAGNOSTIC_TEST	Magnetic Resonance Imaging (MRI)	MRI is a noninvasive, radiation-free medical imaging technique that uses powerful magnets and radio waves to generate detailed, high-resolution 3D images of soft tissues, organs, and bones.

Timeline

• Start date: 2026-03-27
• Primary completion: 2027-05-01
• Completion: 2027-05-01
• First posted: 2026-03-27
• Last updated: 2026-04-03

Locations

1 site across 1 country: United States