NCT07489118

Impact of Protein Source and Polyphenol Complexation in Protein Bars on Metabolic Health

Impact of Consuming Protein and Polyphenol Bars on Metabolic Health

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: North Carolina State University · Academic / Other
• Sex: All
• Age: 18 Years – 64 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to learn if pulse (pea) protein works similar to animal (whey) protein in protein bars consumed by healthy adults. The main questions it aims to answer are: What are the differences in taste and tolerance profiles between pea and whey proteins? What metabolic and immune changes do participants experience while eating them? What gastrointestinal microbiome shifts can be observed in these participants? How incorporation and complexation of polyphenols with these proteins changes the study outcomes? Participants will: Consume 1 protein bar with whey protein, pea protein, pea protein with complexed polyphenols, or pea protein with free polyphenols every day for 2 months. Visit the study site at baseline and end of study for checkups and tests. Fill dietary, food acceptance, gastrointestinal tolerance, and global health questionnaires.

Conditions

• Food Acceptance
• Metabolic Health
• Immune Cells Activity
• Microbiome Composition

Interventions

Type	Name	Description
OTHER	Whey protein bar	Whey protein bar
OTHER	Pea protein bar	Pea protein bar
OTHER	Pea protein with complexed polyphenols bar	Pea protein with complexed polyphenols bar
OTHER	Pea protein with free polyphenols bar	Pea protein with free polyphenols bar

Timeline

• Start date: 2025-05-01
• Primary completion: 2025-09-08
• Completion: 2026-04-01
• First posted: 2026-03-23
• Last updated: 2026-03-23

Locations

1 site across 1 country: United States