NCT07488078

Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery

Effect of Liberal Versus Restrictive Intravenous Fluid Administration on Postoperative Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 380 (estimated)
• Sponsor: King Edward Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn whether giving less intravenous (IV) fluid (restrictive administration) after surgery is as effective as giving more IV fluid (liberal administration) in maintaining body stability (homeostasis) among adults undergoing laparoscopic gallbladder removal (cholecystectomy). The main questions it aims to answer are: Does restrictive IV fluid administration maintain stable blood pressure, heart rate, and urine output after laparoscopic cholecystectomy? Are there any differences in postoperative recovery or complications between restrictive and liberal fluid regimens? Researchers will compare patients receiving liberal IV fluid administration with those receiving restrictive IV fluid administration to see if both methods maintain similar postoperative homeostasis and recovery outcomes. Participants will: Be adults aged 18-60 years (ASA class I-II) undergoing elective laparoscopic cholecystectomy. Be randomly assigned to one of two groups: Group A: Liberal IV fluid administration for 6 hours after surgery. Group B: Restrictive IV fluid administration for 6 hours after surgery. Have their vital signs (pulse, blood pressure, mean arterial pressure) and urine output recorded at multiple time points after surgery (immediate, 3, 6, 12, and 24 hours).

Conditions

• Laparoscopic Cholecystectomy

Interventions

Type	Name	Description
DRUG	Lactated Ringer 500ml	500ml ringer lactate perioperatively given in laparoscopic cholecystectomy patients as compared to traditional 1000ml fluid
DRUG	Lactated Ringer 1000ml	1000ml iv fluid given perioperatively in laparoscopic cholecystectomy

Timeline

• Start date: 2025-12-01
• Primary completion: 2026-07-28
• Completion: 2026-07-28
• First posted: 2026-03-23
• Last updated: 2026-03-23

Locations

1 site across 1 country: Pakistan