NCT07487324

Oxygenation in Posterior Stabilization Surgery

Factors Determining Oxygenation in Posterior Stabilization Surgery: The Role of Positioning and Mechanical Ventilation Parameters

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Sakarya University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effects of prone positioning on oxygenation, ventilation, and hemodynamic parameters in patients undergoing posterior stabilization surgery under general anesthesia. By comparing routine anesthesia and monitoring data obtained in the supine and prone positions, the study seeks to determine how positional changes influence respiratory mechanics and perioperative physiological stability.

Detailed description

The prone position is frequently used during posterior stabilization surgery, yet it is associated with important physiological changes that may affect both respiratory and hemodynamic function under general anesthesia. Previous studies have shown that prone positioning may improve ventilation-perfusion matching, increase functional residual capacity, and enhance oxygenation. At the same time, position-related alterations in thoracic mechanics, airway pressures, venous return, and cardiovascular parameters may influence intraoperative management. This study is designed to comprehensively assess the physiological effects of prone positioning in anesthetized patients undergoing posterior stabilization surgery. Routine anesthesia and monitoring data collected during mechanical ventilation will be analyzed and compared between the supine and prone positions. Particular focus will be placed on oxygenation, ventilation variables, respiratory mechanics, and hemodynamic parameters in order to evaluate the impact of positional change. In addition, the study aims to identify which clinical and monitoring findings should be prioritized during anesthetic management of patients in the prone position. By clarifying the relationship between positioning and perioperative physiological responses, the study seeks to contribute to safer anesthetic practice and to support the maintenance of adequate oxygenation and hemodynamic stability throughout surgery.

Conditions

• Oxygen
• Oxygen Saturation

Interventions

Type	Name	Description
OTHER	blood gase	Arterial blood gas samples will be obtained from patients, and alveolar oxygenation ratios will be compared between the supine and prone positions.

Timeline

• Start date: 2026-04-01
• Primary completion: 2026-10-15
• Completion: 2026-11-15
• First posted: 2026-03-23
• Last updated: 2026-03-23

Locations

1 site across 1 country: Turkey (Türkiye)