NCT07483047

Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 634 (estimated)
• Sponsor: Shanghai Geriatric Medical Center · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective cohort study aiming to construct a prediction model for postoperative cognitive dysfunction (POCD) in elderly cardiac patients. We plan to enroll elderly patients aged ≥65 years undergoing cardiac surgery. Peripheral blood samples and functional magnetic resonance imaging (fMRI) data will be collected at baseline and key time points post-surgery. The primary objectives are to identify novel peripheral blood protein biomarkers for POCD, explore the correlation between fMRI characteristics and POCD, and establish a reliable early prediction model to improve perioperative management and reduce the incidence of POCD in elderly cardiac surgical patients.

Conditions

• Postoperative Cognitive Dysfunction (POCD)
• Cardiac Diseases Requiring Surgery

Timeline

• Start date: 2026-03-03
• Primary completion: 2028-09-01
• Completion: 2028-09-01
• First posted: 2026-03-19
• Last updated: 2026-03-19

Locations

1 site across 1 country: China