NCT07482007

Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates

Comparative Study of Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

comparing the effect of oral care with colostrum, chlorohexidine and sodium bicarbonate in prevention of ventilator-associated pneumonia in preterm neonates.

Detailed description

Randomized controlled trial

Conditions

• Ventilator-Associated Pneumonia

Interventions

Type	Name	Description
OTHER	Oropharyngeal Care with Colostrum	Application of small amounts of expressed maternal colostrum to the oral mucosa of ventilated preterm neonates using sterile swabs every 3-4 hours according to NICU oral care protocol.
DRUG	Chlorhexidine Oral Care	Oropharyngeal care using diluted chlorhexidine solution applied to the oral cavity of ventilated preterm neonates at scheduled intervals according to NICU protocol.
OTHER	Sodium Bicarbonate oral care	Preterm neonates receiving oral care using sodium bicarbonate solution applied to the oral mucosa using sterile swabs.
OTHER	Normal Saline Oral Care	Routine oropharyngeal care using sterile normal saline applied with sterile swabs at regular intervals during mechanical ventilation.

Timeline

• Start date: 2024-04-01
• Primary completion: 2026-01-01
• Completion: 2026-03-01
• First posted: 2026-03-19
• Last updated: 2026-03-19

Locations

1 site across 1 country: Egypt