NCT07481396

Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics

Identification of Novel Molecular Pathophysiological Mechanisms of Secondary Brain Injury in Post-cardiac Arrest Syndrome Patients Using Cerebrospinal Fluid Multi-omics Analysis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Chungnam National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques. The main question this study aims to answer is: Which genome-, transcriptome-, proteome-, and metabolome-level changes in CSF are associated with secondary brain injury after cardiac arrest? To address this question, CSF samples collected from post-cardiac arrest patients will undergo multi-omics analyses. Identified molecular pathways will be used to screen existing drug databases and generate new therapeutic candidates through computational modeling and compound synthesis. These findings will provide the scientific foundation needed to design and implement future preclinical experiments using cardiac arrest animal models.

Conditions

• Cardiac Arrest (CA)
• Cerebrospinal Fluid
• Multiomics
• Hypoxic-Ischemic Brain Injury

Timeline

• Start date: 2025-12-01
• Primary completion: 2027-11-30
• Completion: 2028-02-28
• First posted: 2026-03-18
• Last updated: 2026-03-18

Locations

1 site across 1 country: South Korea