NCT07480876

Glyceryl Trinitrate Gel Phonophoresis on Planter Fasciiatis

Effect of Glyceryl Trinitrate Gel Phonophoresis in Treatment of Plantar Fasciitis: A Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 44 Years
• Healthy volunteers: Not accepted

Summary

Does phonophoresis with glyceryl trinitrate gel have an effect in treatment of planter fasciitis patients?

Detailed description

Plantar fasciitis (PF), considered the most common cause of sub-calcaneal pain, was first described in 1812, related to painful sensation in the calcaneus, resulting from degeneration of the plantar fascia. Some reported cases are the result of biomechanical failure that provides tension along the plantar fascia. It is a common dysfunction in runners, due to the high loads they exert on the plantar fascia, but other risk factors are also worth mentioning, such as increased planter flexion, high body mass and high body mass index phonophoresis emerges as a valuable and versatile modality within physiotherapy, demonstrating clinical efficacy across a spectrum of musculoskeletal and inflammatory conditions. The combination of topically applied gel or cream-based medications with ultrasound therapy, operating within specific frequency and intensity ranges, enhances percutaneous absorption of pharmacological agents. Glyceryl trinitrate can directly relax vascular smooth muscles, especially the smooth muscle of small blood vessels, thus dilating blood vessels and improving the microcirculation. In addition, nitroglycerin interacts with intracellular sulfhydryl to release nitric oxide (NO). NO, as endothelial relaxing factor, activates guanylate cyclase to transform into cyclic guanosine monophosphate (cGMP), which increases cGMP in smooth muscles and other tissues, thereby causing dephosphorylation of myosin light chain, regulating the contractile state of smooth muscles, relaxing smooth muscles, and dilating blood vessels gap in literature about the effect of glyceryl trinitrate gel in treatment of plantar fasciitis. So the aim of this study is to investigate the effect of glyceryl trinitrate gel in treatment of plantar fasciitis.

Conditions

• Planter Fasciitis

Interventions

Type	Name	Description
OTHER	Phonophoresis group	1. Patients will receive Phonophoresis with topical glyceryl trinitrate gel. Using pulsed ultrasound (2:1) with the frequency of 0.8 MHz and intensity of 1.5 W/CM for 10 minutes was dynamically administered for the patients in 10 every other day sessions. 2. Therapeutic exercises * Tibialis anterior strengthening (four sets of ten repetitions, with weights of 3 to 5 kg) * Plantar fascia stretching the patient was comfortably sitting on chair with tennis ball under his foot. Then he rolls the ball by moving his foot in forward and backward direction. * Stretching of the gastrocnemius and gastro soleus muscles by standing (standing calf stretch exercise, standing soleus muscle stretch exercise), the Achilles tendon by sitting (towel stretch exercise) , and the plantar fascia on a step (plantar fascia stretch exercise) . Patients were asked to do the exercises for four weeks, 10 times each morning and evening by counting up to 30
OTHER	ultrasound only and Therapeutic exercises	1. Patients will receive ultrasound at a frequency of 1.0 Hz and intensity of 1.2 watts/cm². Ten sessions were undertaken at a frequency of two sessions per week. 2. therapeutic exercises.

Timeline

• Start date: 2026-04-30
• Primary completion: 2026-09-30
• Completion: 2026-11-30
• First posted: 2026-03-18
• Last updated: 2026-03-24

Locations

1 site across 1 country: Egypt