NCT07480018

Berberine Supplementation, Sprint Interval Training, and Immune Function Study

Effects of 2-Weeks of Berberine and Sprint Interval Training on Wellbeing, Anaerobic Power, and Monocyte Number and Function

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Northern Colorado · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are: * Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality? * Does short-term berberine use or sprint training improve measures of anaerobic power generation? * Does short-term berberine use or sprint training improve circulating biomarkers of inflammation? * Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?

Conditions

• Berberine
• Sprint Training
• Wellbeing
• Anaerobic Power
• Inflammation Biomarkers
• Monocyte Function

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Berberine	Consumption of a commercially-available Berberine supplement at a dosage of 500mg, Three times per day with meals, for a total dosage of 1500mg/day.
OTHER	Placebo	Consumption of placebo capsules composed of rice flour at a dosing of 3 capsules per day with meals.
OTHER	Sprint Interval Training	Multiple sets of maximal effort 30 second sprints, inter spaced with 4 minutes of rest/active recovery, on the cycle ergometer over the course of 6 sessions during the 2-Week intervention. Resistance for each set is calculated at 7.5% of the body mass of the participant. Sets for each session are as follows: (1) 4 Sets, (2) 5 Sets, (3) 6 Sets, (4) 6 Sets, (5) 7 Sets, (6) 4 Sets.

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-05-01
• Completion: 2026-06-01
• First posted: 2026-03-18
• Last updated: 2026-03-18

Locations

1 site across 1 country: United States