NCT07479771

tTIS Targeted of the Striatum as an Intervention for MUD Patients

Transcranial Temporal Interference Stimulation Targeted of the Striatum as an Intervention for Methamphetamine Use Disorder Patients

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Shanghai Mental Health Center · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Targeted temporal interference stimulation (tTIS) of the caudate nucleus can modulate the abnormal electrophysiological activity in individuals with methamphetamine use disorder (MUD), thereby improving their impaired reward-learning behaviors and reducing drug craving.

Detailed description

This project will recruit MUD patients. A 5-day intervention protocol of real or sham tTIS targeting the caudate nucleus will be employed. Before and after intervention, drug craving anddrug use and other questionnaire as well as stop-signal tasks, and reward-learning tasks will be used to evaluate its therapeutic efficacy on clinical craving and the underlying neural mechanisms.

Conditions

• Amphetamine Use Disorders

Interventions

Type	Name	Description
DEVICE	Temporal Interference Stimulation	The stimulation duration are 30 minutes per session, administered twice daily for 5 consecutive days.
DEVICE	Shame	The stimulation parameters-including frequency, current intensity, and duration-are identical to those in the active group. However, the sham stimulation mode is activated on the device, resulting in no actual current being delivered during the stimulation.

Timeline

• Start date: 2026-03-26
• Primary completion: 2026-06-01
• Completion: 2026-06-30
• First posted: 2026-03-18
• Last updated: 2026-03-18

Locations

1 site across 1 country: China