NCT07478237

The Preventive Risk Outreach And Cascade Testing

The Preventive Risk Outreach and Cascade Testing (PROACT)

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to learn whether a new online program developed by the research team is able to help families learn about family cancer risk and how to reduce this risk, as well as help interested family members get low-cost, at-home genetic testing for cancer risk.

Detailed description

The overarching goal of this study is to facilitate cascade genetic testing to reduce the burden of cancer in families with hereditary cancer syndromes (HCS). We will evaluate different versions of a point-of-care cascade genetic testing referral service for probands with recently detected pathogenic or likely pathogenic genetic variants.

Conditions

• Genetic Predisposition
• Family Members

Interventions

Type	Name	Description
OTHER	Minimally facilitated platform	This group will receive access to low-cost genetic testing via an email link and an access code.
OTHER	AI-powered platform	This group will receive access to low-cost genetic testing via an AI-powered platform that will also provide genetic education, motivational interviewing, and family communication

Timeline

• Start date: 2026-06-01
• Primary completion: 2029-12-01
• Completion: 2029-12-01
• First posted: 2026-03-17
• Last updated: 2026-03-17