NCT07478146

Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease

Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Raphael Mendes Ritti Dias · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.

Detailed description

This is a parallel-group randomized controlled trial Participants (n=40) diagnosed with Parkinson's disease, stages 1-3 on Hoehn \& Yahr scale, will be randomly allocated (1:1 block randomization) to: * Aerobic Training Group; * Control Group (usual care) The intervention will last 12 weeks, 3 sessions/week Pre and post-intervention assessments will include: * Cerebrovascular function: neurovascular coupling, cerebrovascular reactivity (breath-holding index), dynamic cerebral autoregulation (transfer function analysis), and acute cerebral blood flow response to exercise (transcranial Doppler; vertebral artery flow during silent reading). * Peripheral vascular and cardiovascular function: brachial artery flow-mediated dilation, carotid intima-media thickness, resting blood pressure, resting heart rate, cardiorespiratory fitness (VO₂peak), heart rate variability (time and frequency domains), and baroreflex sensitivity. * Cognitive performance: Montreal Cognitive Assessment (MoCA), Trail Making Test A and B, and Stroop Color-Word Test. * Gait biomechanics: spatiotemporal parameters, 3D kinematics (Vicon system), and kinetics (force platform). * Clinical and non-motor symptoms: UPDRS, Non-Motor Symptoms Scale (NMSS), sleep quality (PDSS), anxiety (PAS), depressive symptoms (GDS-15), apathy (Apathy Inventory), fatigue (Parkinson Fatigue Scale), pain (Numeric Rating Scale), and quality of life (PDQ-8). * Body composition: quadriceps muscle thickness and subcutaneous adipose tissue thickness assessed by ultrasound. All experimental sessions will be performed in the "on" medication state

Conditions

• PARKINSON DISEASE (Disorder)

Interventions

Type	Name	Description
BEHAVIORAL	Aerobic training	Aerobic Exercise Training
BEHAVIORAL	Usual Care	Usual Care

Timeline

• Start date: 2026-02-28
• Primary completion: 2027-06-30
• Completion: 2027-12-31
• First posted: 2026-03-17
• Last updated: 2026-04-13

Locations

1 site across 1 country: Brazil