NCT07477275

Combination of Oral and Topical Whitening Agents for Reducing Skin Pigmentation

Combination of Oral and Topical Whitening Agents for Reducing Skin Pigmentation in Healthy Women: A Randomized Controlled Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 68 (estimated)
• Sponsor: USMARI Research & Innovation Centre · Industry
• Sex: Female
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to evaluate the safety and efficacy of a combination use of oral supplement and topical serum in improving skin pigmentation in healthy women. The main questions it aims to answer are: Does combination use able to reduce the dark spot? Is there any adverse effect associate with the product use?

Conditions

• Dark Spots

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	oral supplement	Oral supplement need to be consume for 12 weeks. Subject need to consume the capsule once daily, during the first week. After the first week, if there are no adverse effects, they need to consume the capsule twice daily (normal dosage).
OTHER	Retinol serum	Serum need to be apply daily at night only, in a thin layer. The application schedule is as follows: in week 1, once a week; in week 2, twice a week (if no adverse reactions occur in week 1, such as skin dryness); in weeks 3 and 4, twice a week; and from week 4 onwards until the study is completed, three times per week.

Timeline

• Start date: 2024-12-01
• Primary completion: 2026-04-30
• Completion: 2026-04-30
• First posted: 2026-03-17
• Last updated: 2026-03-17

Locations

1 site across 1 country: Malaysia