NCT07475793

Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis

Efficacy of Ultrasound vs Fluoroscopy Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis: A Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (estimated)
• Sponsor: Aga Khan University · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

The goal of this prospective randomized control trial is to provide continued pain relief, classically long-lasting 3 to12 months, and enhanced function in patients following: both gender; male and female, age group; \>50yr, healthy volunteers along with Radiographic diagnosis of knee OA with KL grade 3 and 4 in addition of Chronic knee pain ≥ 6 months and patients with ≥50% decrease in pain strength after diagnostic genicular nerve block. The main question it aims to answer is: Is ultrasound-guided genicular nerve RFA more efficient in lowering pain intensity at six months contrasted with fluoroscopic guided method in patients with chronic knee osteoarthritis? Researchers will compare Group A (Fluoroscopic) to Group B (Ultrasound) to see comparison in efficiency of ultrasound guided against fluoroscopic guided genicular nerves block for decrease in pain intensity and functional improvement.

Conditions

• Chronic Knee Osteoarthritis

Interventions

Type	Name	Description
PROCEDURE	Ultrasound Guided	Genicular nerves radiofrequency ablation will be done with the help of ultrasound guidance.
PROCEDURE	Fluoroscope Guided	Control group in which genicular nerves radiofrequency ablation will be done with the help of fluoroscopic guidance.

Timeline

• Start date: 2026-05-01
• Primary completion: 2027-04-30
• Completion: 2027-05-31
• First posted: 2026-03-17
• Last updated: 2026-03-27