NCT07475780

Radiofrequency Ablation For Recurrent Parathyroid Carcinoma

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study will be an effectiveness study. The study will include enrollment of a total of 20 patients with at least one PC lesion for ultrasound guided RFA to PC recurrence in the neck to assess the effectiveness in reducing patient's hypercalcemia. Patients will have surgically proven PC from prior parathyroidectomy and suspicious PC visible on ultrasound and request for treatment for uncontrolled hypercalcemia (Figure 1).

Detailed description

Primary Objective: • Evaluate treatment response of RFA of recurrent PC by means of longitudinal monitoring patient serum calcium level and PTH. Secondary Objectives: * Evaluate the sonographic features of the recurrent PC induced by RFA. * Evaluation of procedure-related complications * Disease free survival until recurrence of hypercalcemia

Conditions

• Recurrent Parathyroid Carcinoma

Interventions

Type	Name	Description
DEVICE	Ultrasound-guided RFA	Participants will be positioned supine with full neck extension. Preprocedural intraoperative PTH will be drawn. Radiofrequency ablation (RFA) will be performed on one or up to 5 nodules on ipsilateral side per participant.

Timeline

• Start date: 2026-04-09
• Primary completion: 2029-04-30
• Completion: 2031-04-30
• First posted: 2026-03-17
• Last updated: 2026-04-14

Locations

1 site across 1 country: United States