NCT07475182

Exploratory Clinical Study of Targeted Activated DC and CAR-T Therapy in Advanced Solid Cancers

Exploratory Clinical Study of Targeted Activated DC and CAR-T Therapy in Patients With Advanced Solid Cancers.

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Hainan Cancer Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This is an open-label, single-arm clinical study designed to evaluate the safety and preliminary efficacy of Targeted Activated DC combined with CAR-T therapy in patients with Advanced Solid Cancers.This combination therapy activates dendritic cells (DCs) to precisely target the tumor site, reshaping the tumor immune microenvironment, breaking down the immunosuppressive barrier, and allowing CAR-T cells to penetrate deeper into the tumor more efficiently, precisely and persistently killing cancer cells.

Conditions

• Advanced Solid Cancers

Interventions

Type	Name	Description
BIOLOGICAL	Targeted Activated Dendritic Cells	Autologous dendritic cells (DCs) genetically modified to express chimeric antigen receptor (CAR) and activation domain
BIOLOGICAL	Targeted CAR-T Cells	Autologous T cells genetically modified to express chimeric antigen receptor (CAR)

Timeline

• Start date: 2025-12-06
• Primary completion: 2027-12-06
• Completion: 2028-06-06
• First posted: 2026-03-16
• Last updated: 2026-03-16

Locations

1 site across 1 country: China