NCT07472010

Mandibular Stretching and 4-4-8 Breathing Exercises on Autonomic Nervous System Activity

Investigation of the Effects of Mandibular Stretching Exercise and 4-4-8 Breathing Exercise on Autonomic Nervous System Activity, Muscle Tone, and Psychological State: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (estimated)
• Sponsor: Mehin Mammadzada · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Mandibular stretching exercises and breathing techniques may influence autonomic nervous system activity, muscle tone, and psychological state. This randomized controlled trial aims to investigate the effects of mandibular stretching exercise and the 4-4-8 breathing exercise on autonomic nervous system activity, muscle tone, and psychological parameters in healthy university students. Participants will be randomly assigned to intervention groups and evaluated before and after the intervention period.

Detailed description

The autonomic nervous system plays an important role in regulating physiological and psychological responses. Breathing techniques and mandibular stretching exercises are non-invasive approaches that may influence autonomic nervous system activity and muscle tone through neuromuscular and respiratory mechanisms. However, the combined or individual effects of these interventions on autonomic regulation and psychological outcomes remain insufficiently investigated. This randomized controlled trial aims to examine the effects of mandibular stretching exercise and the 4-4-8 breathing exercise on autonomic nervous system activity, muscle tone, and psychological state in healthy university students. Participants will be randomly allocated to intervention groups according to the study protocol. Baseline and post-intervention measurements will be collected to evaluate changes in autonomic nervous system parameters, muscle tone, and psychological status. The findings of this study may contribute to understanding the potential benefits of simple non-pharmacological interventions such as mandibular stretching and breathing exercises in improving physiological regulation and psychological well-being.

Conditions

• Muscle Tone
• Psychological State
• Autonomic Nervous System

Interventions

Type	Name	Description
OTHER	Mandibular Stretching Exercise	Participants perform mandibular stretching exercises according to the study protocol
OTHER	4-4-8 Breathing Exercise	Participants perform the 4-4-8 breathing exercise according to the study protocol.

Timeline

• Start date: 2025-12-15
• Primary completion: 2026-03-15
• Completion: 2026-06-19
• First posted: 2026-03-16
• Last updated: 2026-03-16

Locations

1 site across 1 country: Turkey (Türkiye)