NCT07470112

Efficacy of Local Gentamicin Containing Collagen In Prevention of Post Stermotomy Infection In Cardiac Surgery

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 142 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The local application of gentamicin-containing collagen implants reduces the incidence of surgical site infections in high-risk cardiac surgery patients compared to standard prophylactic measures alone.

Detailed description

Surgical procedure: * Standard median sternotomy and cannulation for cardiopulmonary bypass. All procedures will be performed on heparin bonded cardiopulmonary bypass circuits with a membrane oxygenator. * Closure technique: Patients in our study will be divided into two groups: Gentamycin Group: Patients in this group had local sternal Gentamycin containing collagen between two edges of the sternum. (Gentamycincontaining collagen will be applied to retrosternal and between both sternal halves similar to bone wax just prior to sternal wiring (T-SHAPED. ) Control Group: Patients in this group sternum will be closed without application of local Gentamycin containing collagen.

Conditions

• Surgical Site Infection (SSI)

Interventions

Type	Name	Description
PROCEDURE	Gentamycin	Patients in this group had local sternal Gentamycin containing collagen between two edges of the sternum.
PROCEDURE	bone wax	Patients in this group sternum will be closed without application of local Gentamycin containing collagen.

Timeline

• Start date: 2025-05-20
• Primary completion: 2026-03-01
• Completion: 2026-05-01
• First posted: 2026-03-13
• Last updated: 2026-03-13

Locations

1 site across 1 country: Egypt