NCT07466654

Low-Dose Caffeine and Taurine Effects on Performance

Synergistic Effects of Low-Dose Caffeine and Taurine on Anaerobic, Neuromuscular, and Cognitive Performance: A Double-Blind Randomized Placebo-Controlled Crossover Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Ankara University · Academic / Other
• Sex: Male
• Age: 18 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the effects of low-dose caffeine and taurine, administered separately and in combination, on anaerobic, neuromuscular, and cognitive performance. The study is designed as a randomized, double-blind, placebo-controlled crossover trial involving trained man participants. Each participant will complete experimental sessions under different supplementation conditions, including caffeine, taurine, their combination, and placebo. Performance outcomes will include anaerobic power, neuromuscular performance, and cognitive function assessments. The findings will help clarify whether the combined ingestion of caffeine and taurine produces synergistic performance effects compared with isolated supplementation.

Detailed description

Caffeine and taurine are commonly consumed ingredients in coffee and energy drinks and are frequently used as ergogenic aids to enhance physical and cognitive performance. Although both compounds have been widely investigated individually, evidence regarding their combined effects remains limited and inconsistent. Understanding whether caffeine and taurine produce synergistic or additive effects is important for clarifying their role in sports performance and supplementation strategies. The present study is designed as a randomized, double-blind, placebo-controlled crossover trial to examine the isolated and combined effects of low-dose caffeine and taurine on anaerobic, neuromuscular, and cognitive performance in trained individuals. Participants will complete multiple experimental sessions under different supplementation conditions, including caffeine, taurine, their combination, and placebo. During each session, participants will undergo standardized performance assessments to evaluate anaerobic power, neuromuscular performance, and cognitive function. The crossover design allows each participant to serve as their own control, minimizing inter-individual variability. The findings of this study may provide further insight into the potential synergistic effects of caffeine and taurine supplementation on performance outcomes.

Conditions

• Anaerobic Performance Neuromuscular Performance Cognitive Performance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Caffeine	Caffeine administered at a dose of 2 mg/kg body mass in capsule form, 60 minutes prior to performance testing.
DIETARY_SUPPLEMENT	taurine	Taurine administered at a dose of 10 mg/kg body mass in capsule form, 60 minutes prior to performance testing.
DIETARY_SUPPLEMENT	Caffeine + Taurine	Combined supplementation of caffeine (2 mg/kg) and taurine (10 mg/kg) administered 60 minutes prior to testing.
DIETARY_SUPPLEMENT	Placebo	Placebo capsule containing maltodextrin (300 mg) administered 60 minutes prior to testing.

Timeline

• Start date: 2025-10-15
• Primary completion: 2025-11-15
• Completion: 2025-11-15
• First posted: 2026-03-12
• Last updated: 2026-03-12

Locations

1 site across 1 country: Turkey (Türkiye)