Trials / Recruiting
RecruitingNCT07466290
L-serine and Strength Training in the Elderly
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 126 (estimated)
- Sponsor
- University of Vienna · Academic / Other
- Sex
- All
- Age
- 65 Years – 85 Years
- Healthy volunteers
- Accepted
Summary
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people. Healthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training. Cognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.
Detailed description
The study is a randomized, controlled, double-blind intervention study with three parallel groups of healthy older adults (aged 65-85). It investigates the effects of L-serine supplementation with and without accompanying strength training on cognitive, neural, molecular, and functional parameters over 48 weeks. The primary endpoint is the change in cognitive performance, measured using the composite RBANS score. Secondary endpoints include structural and functional brain parameters (MRI, EEG), psychosocial parameters, markers of oxidative stress and immune function, as well as physical performance and muscle mass.
Conditions
- Brain Health
- Longevity
- Cognitive Performance
- Strength Training Effects
- Healthy Ageing
- Ageing
- Cognition
- Memory
- Muscle Strength
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Strength training | Structured strength training 2x/week |
| DIETARY_SUPPLEMENT | L-serine supplementation | L-serine supplementation 6g/day |
| DIETARY_SUPPLEMENT | Control (cornstarch) | Placebo 6g cornstarch/day, No strength training |
Timeline
- Start date
- 2026-03-01
- Primary completion
- 2027-12-01
- Completion
- 2028-12-01
- First posted
- 2026-03-12
- Last updated
- 2026-03-12
Locations
1 site across 1 country: Austria
Source: ClinicalTrials.gov record NCT07466290. Inclusion in this directory is not an endorsement.