NCT07463859

Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus

Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus: A Randomized Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate the effectiveness of periodontal treatment associated with the use of a tongue scraper, compared with the same treatment combined with antimicrobial photodynamic therapy (aPDT), in reducing halitosis in individuals with periodontal disease and type 2 diabetes mellitus. The main question it aims to answer is: aPDT treatment is more effective in treating halitosis? aPDT treatment is more effective in periodontitis? Researchers will compare aPDT treatment to conventional treatment (scaling and root planning and tongue scraper) to see if aPDT has additional effects in reducing halitosis and improving periodontal health. * Participants will be asked to visit the clinic once a week for exam and treatment during 1 month. * After active treatment they will be asked to come to maintenance and control visits once a month until 6 months.

Conditions

• Type 2 Diabetes
• Halitosis
• Periodontitis

Interventions

Type	Name	Description
PROCEDURE	Scaling and root planing	Mechanical removal of biofilm in periodontal pockets and tongue
PROCEDURE	Photodynamic Therapy with Conventional Methylene Blue	Antimicrobial photodynamic therapy in periodontal pockets and tongue

Timeline

• Start date: 2026-04-02
• Primary completion: 2027-01-31
• Completion: 2027-02-28
• First posted: 2026-03-11
• Last updated: 2026-03-16

Locations

1 site across 1 country: Brazil