NCT07463053

Mass Balance and Absolute Bioavailability Study of JMKX003142 In Healthy Volunteers

A Study to Evaluate the Mass Balance and Absolute Bioavailability of [14C]JMKX003142 in Healthy Male Participants

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 8 (estimated)
• Sponsor: Jemincare · Industry
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

A phase 1 healthy volunteer study to assess the excretion and metabolism as well as the absolute bioavailability of oral JMKX003142. The study will be conducted in two parts: Part 1 to assess the mass balance of JMKX003142 using orally administered radiolabelled JMKX003142; part 2 will assess the absolute bioavailability using JMKX003142 and radiolabelled JMKX003142 as intravenous and oral forms

Conditions

• ADPKD (Autosomal Dominant Polycystic Kidney Disease)

Interventions

Type	Name	Description
DRUG	[14C]JMKX003142	Participants will receive oral \[14C\]JMKX003142
DRUG	JMKX003142 tablets	Participants will receive oral JMKX003142
DRUG	[14C]JMKX003142 solution for infusion	Participants will receive IV \[14C\] JMKX003142

Timeline

• Start date: 2026-03-18
• Primary completion: 2026-05-07
• Completion: 2026-06-11
• First posted: 2026-03-10
• Last updated: 2026-03-10